Steven Murkli

In Vitro and In Vivo Sequestration of Phencyclidine by Me4 Cucurbit[8]uril*.

Chemistry - A European Journal February 10, 2021 Steven Murkli, Jared Klemm, Adam T. Brockett et al.

We report investigations of the use of cucurbit[8]uril (CB[8]) macrocycles as an antidote to counteract the in vivo biological effects of phencyclidine. We investigate the binding of CB[8] and its derivative Me4 CB[8] toward ten drugs of abuse (3-9, 12-14) by a combination of 1 H NMR spectroscopy and isothermal titration calorimetry in phosphate buffered water. We find that the cavity of CB[8]...