Novel GPR18 Ligands in Rodent Pharmacological Tests: Effects on Mood, Pain, and Eating Disorders.
International Journal of Molecular Sciences May 20, 2023 Małgorzata Frankowska, Karolina Wydra, Agata Suder et al.
The lack of selective pharmacological tools has limited the full unraveling of G protein-coupled receptor 18 (GPR18) functions. The present study was aimed at discovering the activities of three novel preferential or selective GPR18 ligands, one agonist (PSB-KK-1415) and two antagonists (PSB-CB-5 and PSB-CB-27). We investigated these ligands in several screening tests, considering the...
DOI: 10.3390/ijms24109046 (opens in new tab)
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Anxiety
Depression
Gpr18 ligands
Food intake
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