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Ana G Gutiérrez-García

2 papers in the library · 5 citations · publishing 2024-2025

Papers

Ketamine and fluoxetine exert similar actions on prelimbic and infralimbic responsivity to lateral septal nucleus stimulation in Wistar rats.

Neuroscience Letters June 21, 2024 Carlos M Contreras, Ana G Gutiérrez-García 4 citations

Ketamine, a dissociative anesthetic proposed for treatment-resistant depression, produces beneficial clinical effects only after its psychotropic actions fade, suggesting dose-independent mechanisms. This study compared an anesthetic dose of ketamine with a high dose of fluoxetine in Wistar rats 24 hours after administration. Fluoxetine reduced immobility in the forced swim test without affecting locomotor activity, while ketamine strongly decreased locomotor activity and did not change immobility. In separate rats, lateral septal nucleus (LSN) stimulation produced a long-lasting inhibitory afterdischarge in prelimbic and infralimbic cortices. Both ketamine and fluoxetine accentuated this inhibition, indicating that despite different neurotransmission actions, antidepressants may share a common final pathway involving forebrain structures linked to emotional regulation.

DOI: 10.1016/j.neulet.2024.137848 (opens in new tab) Full text (opens in new tab) Ketamine Fluoxetine Infralimbic cortex Lateral septal nucleus +7

Differential Actions of Ketamine on CA3-Prelimbic and CA3-Infralimbic Connection Responsivity Depend on Prior Exposure to Stress.

Behavioural Brain Research June 27, 2025 Carlos M Contreras, Ana G Gutiérrez-García 1 citation

A 15-minute forced swim session in male Wistar rats altered the responsiveness of connections between the hippocampal CA3 region and the medial prefrontal cortex (mPFC). Ketamine, given 60 minutes after the stressor, reduced immobility in a later swim test without affecting general locomotion. In the mPFC, CA3 stimulation normally inhibited the prelimbic region and excited the infralimbic region; ketamine reversed the infralimbic response to inhibition. Prior stress amplified the inhibitory response in the infralimbic region, an effect that ketamine abolished. The prelimbic region's response was sensitive to stress but not to ketamine, whereas the infralimbic region's response was sensitive to ketamine only when stress had occurred.

DOI: 10.1016/j.bbr.2025.115712 (opens in new tab) Full text (opens in new tab) Ketamine Forced swim test Infralimbic cortex Stress-sensitive +9