Association of the delayed changes in glutamate levels and functional connectivity with the immediate network effects of S-ketamine
Translational Psychiatry February 16, 2023 Lena Vera Danyeli, Zümrüt Duygu Sen, Lejla Colic et al. 15 citations
Abstract Ketamine shows rapid antidepressant effects peaking 24 h after administration. The antidepressant effects may occur through changes in glutamatergic metabolite levels and resting-state functional connectivity (rsFC) within the default mode network (DMN). A multistage drug effect of ketamine has been suggested, inducing acute effects on dysfunctional network configuration and delayed...