Planar cell polarity proteins mediate ketamine-induced restoration of glutamatergic synapses in prefrontal cortical neurons in a mouse model for chronic stress.
Nature Communications June 10, 2024 Andiara E Freitas, Bo Feng, Timothy Woo et al. 9 citations
Single administration of low-dose ketamine has both acute and sustained anti-depressant effects. Sustained effect is associated with restoration of glutamatergic synapses in medial prefrontal cortic (mFPC) neurons. Ketamine induced profound changes in a number of molecular pathways in a mouse model for chronic stress. Cell-cell communication analyses predicted that planar-cell-polarity (PCP)...
DOI: 10.1038/s41467-024-48257-6 (opens in new tab)
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Ketamine
Antidepressants
Brain research
Mental health