Riluzole blocks HU210-facilitated ventral tegmental long-term depression by enhancing glutamate uptake in astrocytes.
Neuroscience Letters June 21, 2019 Zhiqiang Liu, Yi Xu, Xiaofan Zhang et al.
The lifetime prevalence of addiction to cannabis (marijuana or cannabinoids) is among the highest of that of all illicit drugs in developed countries, and no effective treatment for cannabis addiction is currently available. Previous studies in our research group suggested that astrocyte-mediated long-term depression (LTD) in ventral tegmental area (VTA) dopamine neurons plays a pivotal role in...
DOI: 10.1016/j.neulet.2019.04.021 (opens in new tab)
Full text (opens in new tab)
Astrocyte
Glutamate transporter-1
Hu210
Long-term depression
+1