Improvement in depressive symptoms in a patient with severe and enduring anorexia nervosa and comorbid major depressive disorder using psychotherapy-assisted IV ketamine : a case report.
Journal of Eating Disorders June 12, 2024 Amanda Timek, Catherine Daniels-Brady, Stephen Ferrando 8 citations
A 33-year-old woman with severe and enduring anorexia nervosa (body mass index 13, the lowest documented in the literature) and comorbid major depressive disorder, who had not improved with antidepressants, mood stabilizers, antipsychotics, electroconvulsive therapy, or multiple therapies, received seven sessions of intravenous ketamine combined with acceptance and commitment therapy in a hospital setting. She showed increased cognitive flexibility, disappearance of suicidal ideation, and reduction in Beck Depression Inventory scores. Ketamine-assisted psychotherapy may be a promising treatment for patients with anorexia nervosa and co-morbid depression who have not responded to other interventions.