[Targeting NMDAR/AMPAR: a promising pharmacotherapeutic approach for depressive disorders].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 2024 D V Kurkin, E I Morkovin, D A Bakulin et al.
Depression is a leading cause of disability and reduced work capacity worldwide. The monoamine theory of the pathogenesis of depression has remained dominant for many decades, however, drugs developed on its basis have limited efficacy. Exploring alternative mechanisms underlying this pathology could illuminate new avenues for pharmacological intervention. Targeting glutamatergic pathways in...