Distinct synaptic mechanisms drive the behavioral response to acute stress and rapid correction by ketamine.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology November 1, 2024 Ji-Woon Kim, Benjamin Kleinfelter, Ege T Kavalali et al. 3 citations
Prevailing hypotheses on the mechanisms of antidepressant action posit that antidepressants directly counteract deficiencies in major neurotransmitter signaling systems that underlie depression. The rapidly acting antidepressant ketamine has been postulated to correct excess glutamatergic signaling via glutamatergic antagonism leading to the rescue of neuronal structural deficits and reversal...