Study on the antidepressant activity of (2R,6R; 2S,6S)-Hydroxynorketamine (HNK) and its derivatives.
Clinics 2024 Dongdong Zang, Xuemei Yang, Hao Wang et al. 4 citations
This study mainly explores (2R,6R; 2S,6S)-HNK and its compounds whether there are antidepressant effects. Four HNK compounds were obtained from 2-(Chlorophenyl) Cyclopentylmethanone. Forced swimming test, locomotor sensitization test, and conditioned location preference test were used to screen the antidepressant activity of the synthesized target compounds. In the case of 10 mg HNK treatment,...
DOI: 10.1016/j.clinsp.2024.100435 (opens in new tab)
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Behavioral sensitization test
Forced swimming test
Antidepressants antidepressant medication
Depression medication
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