M R Seggel

Indolealkylamine analogs share 5-HT2 binding characteristics with phenylalkylamine hallucinogens.

European Journal of Pharmacology 1988 R A Lyon, M Titeler, M R Seggel et al.

Twenty-one indolealkylamines, some of which are known to be psychoactive in man, were examined for their binding interactions with rat brain cortical 5-HT2 receptors labeled with the antagonist radioligand [3H]ketanserin in order to develop structure-activity relationships for binding at these sites. Features investigated included aromatic, alpha-methyl and terminal amine substituents....