Genetic ablation of the isoform γ of PI3K decreases antidepressant efficacy of ketamine in male mice.
IBRO Neuroscience Reports December 1, 2024 Gabriela N Vaz, Flávia C Turcato, Isabel A V Lima et al.
About one-third of major depressive disorder (MDD) patients demonstrate unresponsiveness to classic antidepressants, and even the clinical efficacy of fast-acting drugs such as ketamine varies significantly among patients with treatment-resistant depression. Nevertheless, the lack of suitable animal models that mimic a possible ketamine-resistant phenotype challenges the understanding of...