Methylenedioxymethamphetamine induces opposite changes in central pre- and postsynaptic 5-HT1A receptors in rats.
European Journal of Pharmacology July 1, 1995 Norberto Aguirre, J L Galbete, Berta Lasheras et al.
The present study examined the short- and long-term effects of single and repeated administration of 3,4-methylenedioxy-methamphetamine (MDMA, 'ecstasy') on somatodendritic and postsynaptic 5-HT1A receptors of the rat brain. [3H]8-Hydroxy-2-(di-n-propylamino)tetralin ([3H]8-OH-DPAT) was used to label 5-HT1A receptors in the brain stem region containing the dorsal raphe nucleus and in the...
DOI: 10.1016/0014-2999(95)00303-3 (opens in new tab)
Raphe nuclei
Frontal lobe
Dendrites
Synapses
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