A Malyala

Effect of acute monoamine depletion on 3,4-methylenedioxymethamphetamine-induced neurotoxicity.

Pharmacology, Biochemistry, and Behavior July 1, 1993 J Brodkin, A Malyala, J F Nash

The effect of acute, reversible depletion of either serotonin [5-hydroxytryptamine (5-HT)] or dopamine (DA) on the long-term (7-day) decrease of brain 5-HT content produced after 3,4-methylenedioxymethamphetamine (MDMA) administration was investigated. The tyrosine hydroxylase inhibitor alpha-methyl-p-tyrosine (alpha-MPT) significantly attenuated the acute increase in DA efflux produced by MDMA...