D J LaPorte

Absence of ketamine effects on memory and other cognitive functions in schizophrenia patients.

Journal of Psychiatric Research September 1, 1996 D J LaPorte, Adrienne C. Lahti, B Koffel et al.

Glutamatergic dysfunction may play an important role in both the pathophysiology of schizophrenia, and impaired memory commonly observed in that disorder. NMDA receptor antagonists impair learning/memory in animal models, putatively based on its ability to block long-term potentiation (LTP) in the hippocampus. Although well studied in animal models, research in humans is limited and confounded...