A Maurset

Interaction of the chiral forms of ketamine with opioid, phencyclidine, sigma and muscarinic receptors.

Pharmacology & Toxicology December 1, 1995 O Hustveit, A Maurset, I Oye

In order to elucidate the mechanisms of action of ketamine, we have investigated the binding of the chiral forms of ketamine to opioid (mu, delta and kappa), phencyclidine, sigma and muscarinic receptors and we have performed detailed concentration-response experiments in the guinea-pig ileum preparation. The affinity ratios for the chiral forms at phencyclidine, mu and kappa receptors...