Shinichiro Hitomi

2 papers in the library · publishing 1995

Papers

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Dose-dependent effects of repeated ketamine administration on muscarinic acetylcholine receptors in the mouse forebrain.

Journal of Anesthesia September 1, 1995 Shinichiro Hitomi, Toshihito Morita, Shigeru Saito et al.

To study the effects of repeated ketamine administration (0: saline, 12.5, 25, and 50 mg·kg-1 every 3 days for a total of five times, subcutaneously) on the central muscarinic acetylcholine receptors (mAchRs), receptor binding assays of mAchR were carried out in the forebrain of mice, using [3H]quinuclidinyl benzilate ([3H]QNB) as a ligand. We also examined whether repeated ketamine...

DOI: 10.1007/bf02479877 Ketamine Forebrain Up-regulation Muscarinic acetylcholine receptors

Repeated ketamine administration produces up-regulation of muscarinic acetylcholine receptors in the forebrain, and reduces behavioral sensitivity to scopolamine in mice.

Psychopharmacology February 1995 T Morita, Shinichiro Hitomi, S Saito et al.

To study the effects of repeated ketamine administration on central muscarinic acetylcholine receptors (mAchRs), ddY male mice were administered subcutaneous doses of 25 mg/kg ketamine every 3 days for a total of five times. Receptor binding assays of mAchR were carried out in the forebrain (FB), cerebellum (CB) and brainstem (BS), using [3H]quinuclidinyl benzilate ([3H]QNB) as a ligand. In...

DOI: 10.1007/bf02246210 Full text