mTORC1 activation in presumed classical monocytes: observed correlation with human size variation and neuropsychiatric disease.
Aging July 26, 2024 Karl Berner, Naci Oz, Alaattin Kaya et al. 1 citation
Gain of function disturbances in nutrient sensing are likely the largest component in human age-related disease. Mammalian target of rapamycin complex 1 (mTORC1) activity affects health span and longevity. The drugs ketamine and rapamycin are effective against chronic pain and depression, and both affect mTORC1 activity. Our objective was to measure phosphorylated p70S6K, a marker for mTORC1...