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Anna C Renner

4 papers in the library · publishing 2025-2026

Papers

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Chemical Design and Pharmacokinetics Enable Precision Psychedelic Therapeutics.

ACS Medicinal Chemistry Letters January 12, 2026 Anna C Renner, Robert B Kargbo

Recent psychedelic patent activity highlights a strategic shift from experiential framing toward chemically and pharmacokinetically precise neurotherapeutics. Four recent patent applications collectively span solid-state control of psilocybin, exposure-shaped intramuscular and infusion-based dosing, and chemically diversified monoaminergic scaffolds with defined transporter and receptor...

From Solid-State Control to Predictive Precision: Building a Deployable Ecosystem for Psychedelic Therapeutics.

ACS Medicinal Chemistry Letters January 12, 2026 Anna C Renner, Robert B Kargbo

Two recent patent applications illustrate how psychedelic drug development is expanding beyond molecules and experiences toward deployable therapeutic systems. One focuses on solid-state optimization of a lysergamide analogue to ensure manufacturability and stability, while the other applies machine-learning-driven neurophysiological biomarkers to predict patient response. Together, they...

Engineering the Next Generation of Psychedelic Therapeutics through Serotonergic Precision and Pharmacokinetic Control.

ACS Medicinal Chemistry Letters November 10, 2025 Anna C Renner, Robert B Kargbo

High Resolution Image Download MS PowerPoint Slide Recent patents unveil a new wave of psychedelic analogs optimized for 5-HT 2 A receptor modulation, reduced adverse effects, and tunable duration of action. By refining DMT and psilocin scaffolds through prodrug design, fluorination, and structure–activity exploration, these innovations promise safer, shorter-acting psychedelic medicines that...

Toward Precision Psychedelic Therapies: Chemical, Computational, and Neuromodulatory Innovations.

ACS Medicinal Chemistry Letters October 9, 2025 Anna C Renner, Robert B Kargbo

Recent patents disclose complementary strategies to optimize psychedelic-assisted therapy. Novel psilocin prodrugs improve pharmacokinetics and stability, while digital systems enable cognitive state monitoring during treatment. Parallel advances in combining neuroplastogen drugs with transcranial electrical stimulation highlight a model-driven approach to enhance and personalize neural...