Ken Solt

2 papers in the library · publishing 2018-2025

Papers

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REcovery from DEXmedetomidine-Induced Unresponsiveness (REDEX): A Study Protocol for a Single Center, Parallel Arm, Non-Randomized, Controlled Pilot Trial in Healthy Volunteers.

Nature and Science of Sleep 2025 David R Schreier, Matteo Fecchio, Christian S. Guay et al.

Dexmedetomidine (DEX) is a well-tolerated sedative drug that induces a sleep-like state. DEX sedation offers a model to study transitions between different states of consciousness (indicated by, eg, behavior, the electroencephalogram (EEG), or transcranial magnetic stimulation (TMS) evoked EEG responses). However, the effects of repeated DEX exposure on recovery are poorly understood and will...

DOI: 10.2147/NSS.S523111 Full text Consciousness Electroencephalography Sleep Target-controlled infusion +4

Using Anesthesia to Reveal the Elements of Consciousness.

Trends in Cognitive Sciences August 10, 2018 Ken Solt

General anesthesia provides an invaluable experimental tool to probe the essential neural circuits that underlie consciousness. A new study reports that cholinergic stimulation of the prefrontal cortex restores wake-like behaviors in anesthetized rodents, suggesting that cholinergic inputs to the prefrontal cortex play a fundamental role in modulating consciousness.

DOI: 10.1016/j.tics.2018.07.016 Full text Prefrontal cortex Parietal lobe Acetylcholine Anesthesia +3