Experimenter administered Δ9-THC decreases nicotine self-administration in a rat model.
Pharmacology, biochemistry, and behavior October 2023 Antony D Abraham, Jenny L Wiley, Julie A Marusich
The co-use of nicotine and cannabis has been steadily rising in the United States. Rodent studies suggest that delta-9-tetrahydrocannabinol (THC) could increase addictive qualities of nicotine, but whether repeated THC exposure alters self-administration of nicotine has not been tested. We hypothesized that THC would increase the reinforcing effects of nicotine and alter nicotine intake. Adult...