Esketamine alleviates postoperative depression-like behavior through anti-inflammatory actions in mouse prefrontal cortex.
Journal of Affective Disorders April 1, 2022 Tian-Yuan Wang, H. Weng, Hong-Jin Zhou et al.
The rising incidence of Postoperative depression (POD) in recent years has placed a heavy burden on patients' physical and mental health. At this point in time, however, POD pathogenesis remains poorly understood and novel therapeutic strategies are being sought. The present study aimed to clarify esketamine's protective effects and possible mechanisms of action in POD. To this avail, we used...