Key considerations for the use of ketamine and esketamine for the treatment of depression: focusing on administration, safety, and tolerability
Expert Opinion on Drug Safety April 27, 2022 M. Kritzer, C. Pae, P. Masand
ABSTRACT Introduction Racemic ketamine, a derivative of phencyclidine, has been used as a dissociative anesthetic since 1970. In 2000, the first randomized controlled trial showed a rapid relief of depressive symptoms. Since then, intravenous ketamine and intranasal S-ketamine have been validated for the treatment of depression and suicidal ideation following dose-response and double-blind...