Ketamine’s rapid antidepressant effects are mediated by Ca2+-permeable AMPA receptors
bioRxiv January 16, 2023 Anastasiya Zaytseva, E. Bouckova, McKennon J. Wiles et al. preprint
Ketamine is shown to enhance excitatory synaptic drive in the hippocampus, which is presumed to underlie its rapid antidepressant effects. Moreover, ketamine’s therapeutic actions are likely mediated by enhancing neuronal Ca2+ signaling. However, ketamine is a noncompetitive NMDA receptor (NMDAR) antagonist that inhibits excitatory synaptic transmission and postsynaptic Ca2+ signaling. Thus, it...