Patrick Zimdars

A Protecting-Group-Free Synthesis of (-)-Salvinorin A.

Chemistry - A European Journal May 20, 2021 Patrick Zimdars, Yuzhou Wang, Peter Metz

A concise enantioselective total synthesis of the neoclerodane diterpene (-)-salvinorin A is reported. The stereogenic center at C-12 was installed by catalytic asymmetric propargylation with excellent enantioselectivity, and the remaining six stereogenic centers were set up highly diastereoselectively under substrate control. As for our previous synthesis of racemic salvinorin A, two...