Philippe McGee

Formal Synthesis of (±)-Salvinorin A via Gold(I) Catalysis.

Chemistry - A European Journal September 1, 2023 Huy Tran, Philippe McGee, Louis Barriault

The formal synthesis of (±)-salvinorin A is presented. Our approach utilizes two distinct gold(I) catalytic processes. The combination of a gold(I)-catalyzed reaction with an intermolecular Diels-Alder reaction followed by a gold(I)-catalyzed photoredox reaction generated in eight steps the framework of the natural product with high diastereoselectivity.