Retracing our steps to understand ketamine in depression: A focused review of hypothesized mechanisms of action
Mental Health Clinician May 1, 2021 Madison N. Irwin, Amy VandenBerg
AbstractIntroductionMDD represents a significant burden worldwide, and while a number of approved treatments exist, there are high rates of treatment resistance and refractoriness. Ketamine, an N-methyl-d-aspartate receptor (NMDAR) antagonist, is a novel, rapid-acting antidepressant, however the mechanisms underlying the efficacy of ketamine are not well understood and many other mechanisms...