Differentially regulated targets in the fast-acting antidepressant effect of (R)-ketamine: A systems biology approach.
Pharmacology, biochemistry, and behavior February 2023 Ellen Scotton, Pedro Lenz Casa, Fernanda Pessi De Abreu et al.
Approximately two-thirds of patients with major depressive disorder (MDD) fail to respond to conventional antidepressants, suggesting that additional mechanisms are involved in the MDD pathophysiology. In this scenario, the glutamatergic system represents a promising therapeutic target for treatment-resistant depression. To our knowledge, this is the first study using semantic approach with...