Ketamine modulates disrupted in schizophrenia-1/glycogen synthase kinase-3β interaction.
Frontiers in Molecular Neuroscience 2024 Jia-Ren Liu, Xiao Hui Han, Koichi Yuki et al. 4 citations
Disrupted in schizophrenia-1 (DISC1) is a scaffolding protein whose mutated form has been linked to schizophrenia, bipolar affective disorders, and recurrent major depression. DISC1 regulates multiple signaling pathways involved in neurite outgrowth and cortical development and binds directly to glycogen synthase kinase-3β (GSK-3β). Since ketamine activates GSK-3β, we examined the impact of...