State-specific inhibition of NMDA receptors by memantine provides insight into NMDAR channel blocker tolerability
Science Advances May 27, 2026 Matthew B. Phillips, Nadya V. Povysheva, Elizabeth G. Neureiter et al.
N-methyl-d-aspartate (NMDA) receptors (NMDARs) are key mediators of calcium ion (Ca2+) influx required for proper neuronal function. Excessive NMDAR-mediated Ca2+ influx is neurotoxic and associated with neurological disease. Memantine and ketamine, two NMDAR antagonists with overlapping binding sites in the NMDAR channel, are of high clinical interest. Whereas memantine is a well-tolerated...