Journal of Clinical Sleep Medicine
June 17, 2026
Julie Rolling, Lucile Monnier, Thomas Zanfonato et al.
Background: Traumatic nightmares are a core feature in adolescents with complex PTSD (CPTSD) exposed to early and repeated trauma, maintaining hyperactivity and dysregulation. Despite their prevalence and functional impact, targeted treatments for youth remain scarce. Imagery rehearsal therapy (IRT) is a brief cognitive-behavioral intervention effective in adults, but evidence in adolescents...
L'Encephale
June 1, 2026
Pierre A Geoffroy, Sammy Saadi, Sibylle Mauries et al.
Hyperonirism, or "epic dreaming," is an emerging clinical phenomenon characterized by excessive, vivid, and continuous dream activity associated with non-restorative sleep and daytime fatigue. Despite historical descriptions, it remains poorly defined and unrecognized by current nosological systems. We describe four patients assessed in expert sleep and psychiatry centers, presenting with...
Molecular Psychiatry
March 1, 2026
Wilf Gardner, David H. Sarrazin, Martin Balzinger et al.
Disruptions in sleep, circadian rhythms, and neural plasticity are closely linked to the pathophysiology and treatment of depression. Acute sleep deprivation (SD) produces rapid but transient antidepressant effects, yet the underlying mechanisms remain poorly understood. Using a mouse model of stress-induced depression, we found altered sleep architecture, impaired sleep homeostasis, and...
Nature Communications
August 23, 2024
David H. Sarrazin, Wilf Gardner, Carole Marchese et al.
41 citations
Depression is associated with dysregulated circadian rhythms, but the role of intrinsic clocks in mood-controlling brain regions remains poorly understood. We found increased circadian negative loop and decreased positive clock regulators expression in the medial prefrontal cortex (mPFC) of a mouse model of depression, and a subsequent clock countermodulation by the rapid antidepressant...