Prefrontal cortex molecular clock modulates development of depression-like phenotype and rapid antidepressant response in mice.
Nature Communications August 23, 2024 David H. Sarrazin, Wilf Gardner, Carole Marchese et al. 41 citations
Depression is associated with dysregulated circadian rhythms, but the role of intrinsic clocks in mood-controlling brain regions remains poorly understood. We found increased circadian negative loop and decreased positive clock regulators expression in the medial prefrontal cortex (mPFC) of a mouse model of depression, and a subsequent clock countermodulation by the rapid antidepressant...