Cue-elicited prefrontal gamma-aminobutyric acid (GABA) dynamics in cannabis use disorder.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology September 15, 2026 Alexandra Gaillard, Daniel J Fehring, Philip J Sumner et al.
Chronic cannabis use drives neuroadaptations in reward and stress-related circuits that condition the brain to the drug and its associated cues. These changes underlie craving and heighten its sensitivity to cue- and stress-induced triggers, sustaining drug intake and promoting relapse. Task-based functional magnetic resonance imaging of drug cue reactivity paradigms has shown the dorsolateral...