1183 A Randomized, Double-blind, Placebo-Controlled Trial of Doxazosin for Nightmares and Sleep Disturbance in PTSD
Sleep May 1, 2025 A. Richards, L. Yack, Anthony Santistevan et al.
Nightmares and non-nightmare sleep disturbances are a core feature of posttraumatic stress disorder. Effective treatments remain elusive. Doxazosin is an alpha-1 adrenergic blocker with demonstrated promise, but there is a dearth of evidence from randomized controlled trials on its effectiveness. We report findings from a randomized, double-blind, placebo-controlled trial evaluating the...