The Therapeutic Alliance's Moderating Role on the Negative Relationship Between Dread of Ego Dissolution and Changes in Depression Symptom Severity in Psilocybin-Assisted Therapy for Treatment-Resistant Depression: A Secondary Analysis of the PsiDeR Trial.
2026 Canyon Akromis, Lorraine Li, Kwon Mok Ko et al. preprint
This project is a secondary analysis of data from Psilocybin in Depression Resistant to Standard Treatments (PsiDeR) study, a phase II, randomised, placebo-controlled clinical trial where participants with treatment resistant depression received either 25 mg of psilocybin or a placebo alongside psychotherapy. This research seeks to determine whether the therapeutic alliance, measured by the...