Serotonergic transmission plays differentiated roles in the rapid and sustained antidepressant-like effects of ketamine.
British Journal of Pharmacology December 1, 2024 Yong-Yu Yin, Jiao-Zhao Yan, Qian-Qian Wei et al. 13 citations
The emerging antidepressant effects of ketamine have inspired tremendous interest in its underlying neurobiological mechanisms, although the involvement of 5-HT in the antidepressant effects of ketamine remains unclear. The chronic restraint stress procedure was performed to induce depression-like behaviours in mice. OFT, FST, TST, and NSFT tests were used to evaluate the antidepressant-like...