Background: Resting-state fMRI analyses have been used to examine functional connectivity in the aging brain. Recently, fluctuations in the fMRI BOLD signal have been used as a potential marker of integrity in neural systems. Despite its increasing popularity, the results of BOLD variability analyses and traditional seed-based functional connectivity analyses have rarely been compared. The...
We conduct an imaging genetics study to explore how effective brain connectivity in the default mode network (DMN) may be related to genetics within the context of Alzheimer's disease and mild cognitive impairment. We develop an analysis of longitudinal resting-state functional magnetic resonance imaging (rs-fMRI) and genetic data obtained from a sample of 111 subjects with a total of 319...