Microdosing of alteplase leads to thrombolysis in an in vitro flow model of cardiac microvascular obstruction
European Heart Journal October 28, 2024 A Milusev, Y Roesch, P Wolint et al.
Abstract Background Cardiac microvascular obstruction (MVO) is a frequent injury of the myocardial microcirculation after successful recanalisation of the occluded coronary artery in myocardial infarction. At least in part, MVO is caused by embolised microthrombi of less than 200 µm diameter [1]. MVO leads to hypoperfusion of the myocardium and negatively affects patient outcomes. However,...