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Nadine Knowles

1 paper in the library · publishing 2025

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Deuteration may reduce the efficacy of dextromethorphan in treating agitation in Alzheimer’s disease

Alzheimer's Research & Therapy June 9, 2025 Anton Bespalov, Jina Swartz, Nadine Knowles et al.

Abstract Agitation is one of the most prevalent neuropsychiatric symptoms leading to institutionalization in individuals with Alzheimer’s disease (AD) dementia. It is associated with poor outcomes, including reduced functional ability, reduced quality of life, accelerated disease progression, increased mortality, and significant economic burden. Following an initial report demonstrating the...