2,5-dimethoxy-4-methylamphetamine (DOM)-induced Gait Alterations in Mice: Dissecting the Role of 5-HT2A/2C Receptor-mediated Mechanisms.
European Journal of Pharmacology September 15, 2025 Bin Li, Shanshan Jiang, Yi-shan Yao et al.
Psychedelics have demonstrated significant therapeutic potential in treating various psychiatric disorders; however, their effects on motor function remain poorly understood. This study investigated the impact of 2,5-dimethoxy-4-methylamphetamine (DOM), a classical phenethylamine psychedelic agent, on gait parameters in C57BL/6J mice using an active gait monitoring system. We found that 0.3-3...