Research Progress on the Mechanism of Ketamine in Neuropathic Pain Comorbid Depression
Neuropsychiatric Disease and Treatment August 9, 2025 Qing-Mei Li, Shuming Liu, Bangyong Qin et al.
Abstract This review systematically summarizes the research progress of ketamine and its interaction with specific brain regions in the context of neuropathic pain comorbid with depression. As a non-competitive inhibitor of N-methyl-D-aspartate (NMDA) receptors, Ketamine exerts complex mechanisms and controversial topic. The structure and function of NMDA receptors, as well as the binding sites...