Ketamine for major depression in adolescents: a systematic review and meta-analysis of efficacy and safety.
International review of psychiatry (Abingdon, England) 2025 Iury P A Magalhães, Daniel N Lopes, Isabel Amato et al.
Major depressive disorder (MDD) significantly impairs adolescents' development, with increasing rates of treatment resistance and suicide risk. Ketamine has emerged as a promising, rapid-acting antidepressant in adults, but its efficacy and safety in adolescents remain unclear. This systematic review and meta-analysis aimed to evaluate short-term outcomes of ketamine administration in youth...