Ketamine for major depression in adolescents: a systematic review and meta-analysis of efficacy and safety.
International Review of Psychiatry 2025 Iury P A Magalhães, Daniel N. Lopes, Isabel Amato et al.
Major depressive disorder (MDD) significantly impairs adolescents' development, with increasing rates of treatment resistance and suicide risk. Ketamine has emerged as a promising, rapid-acting antidepressant in adults, but its efficacy and safety in adolescents remain unclear. This systematic review and meta-analysis aimed to evaluate short-term outcomes of ketamine administration in youth...
DOI: 10.1080/09540261.2025.2581238 (opens in new tab)
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Ketamine
Treatment-resistant depression
Adolescents
Major depression
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