A systematic review of ketamine's anxiolytic potential in rodent behavioral models of anxiety and PTSD.
Pharmacology, biochemistry, and behavior February 2026 Alena Lemeshova, Kaya A Patel, Alexander J Bloom et al.
Ketamine, a nonselective NMDA-receptor antagonist, is an emerging therapeutic for treatment-resistant depression and could also be a promising treatment for anxiety and post-traumatic stress disorders. However, preclinical studies in these areas lack methodological standardization, limiting clinical translatability. This review evaluates ketamine's anxiolytic potential in rodents by examining...