Testosterone modulation of default mode network and its effects on cognitive function and mood in humans: a systematic review
Frontiers in Neuroscience September 14, 2026 Daria Malich, Andrii Vasylyshyn
Testosterone exerts widespread effects on brain structure and function, yet its influence on large-scale neural networks, particularly the default mode network (DMN), remains poorly understood. The role of the DMN in self-referential processing, social cognition, and mood regulation has been demonstrated over the last decade. Neuroimaging studies suggest a link between testosterone and...