455. Effects of adolescent cannabinoid exposure on DNA methylation in Erbb4 conditional knockout and wild-type mice
International Journal of Neuropsychopharmacology September 1, 2026 Z. Li, D. Mukherjee, E. Dempster et al.
Abstract Background Adolescent cannabis use is associated with an increased risk of psychosis, yet the underlying molecular mechanisms remain poorly understood. Emerging evidence also pointed to genetic liability shaping individual risk of cannabis-induced psychosis. The neuregulin–ErbB4 signalling pathway, implicated in schizophrenia-related neurodevelopment, may modulate individual...