The role of subcortical brain tissue iron as an indicator of dopamine neurophysiology in adolescent cannabis use.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology June 2, 2026 Sarah A Thomas, Meghan A Gonsalves, Gillian LeBlanc et al.
Approximately 10-20% of U.S. adolescents report past-year cannabis use (CU). Although regular CU beginning in adolescence is expected to blunt dopamine-related neurophysiology, this hypothesis has not been tested in adolescents due to methodological limitations. However, neurophysiology contributing to dopamine can be noninvasively indexed via subcortical tissue iron measured with magnetic...