686. Glutamate dysfunction in treatment-resistant depression: translational and clinical insights
The International Journal of Neuropsychopharmacology September 1, 2026 M di Nicola, M Pepe, G Martinotti
Abstract Background Treatment-resistant depression (TRD) represents a major clinical challenge and is associated with substantial symptom burden, functional impairment, and poor prognosis. Beyond traditional monoaminergic models, converging evidence indicates that dysfunction of the glutamatergic system plays a central role in the pathophysiology of TRD, contributing to impaired neuroplasticity...