Chronic sensing during subcallosal cingulate deep brain stimulation captures ketamine-associated changes in major depressive disorder
medRxiv September 11, 2026 Srdjan Sumarac, Tristan Lawson, Leonardo Favi Bocca et al. preprint
Ketamine and subcallosal cingulate (SCC) deep brain stimulation (DBS) have each shown antidepressant effects in treatment-resistant depression, yet how ketamine modulates SCC physiology during chronic stimulation remains poorly understood. We analyzed 5,907 hours of bilateral SCC sensing, 485 participant-triggered recordings across 193 days, 47 ketamine dosing episodes, and an in-clinic...