Psychotomimesis mediated by kappa opiate receptors.
Science (New York, N.Y.) August 15, 1986 A Pfeiffer, V Brantl, A Herz et al.
The kappa opioid agonists are analgesics that seem to be free of undesired morphine-like effects. Their dysphoric actions observed with the kappa agonist cyclazocine are thought to be mediated by an action at sigma-phencyclidine receptors. The benzomorphan kappa agonist MR 2033 is inactive at sigma-phencyclidine receptors. In male subjects, the opiate-active (-)-isomer, but not the (+)-isomer,...